Personnel
Carol Bult
Staff Scientist
The Jackson Laboratory
(207)288-6324
carol.bult@jax.org
http://www.jax.org/staff/carol_bult.html
Lab Members: Masaaki Furuno
Research:
Integration of genomic and biological data in the mouse.
Dr. Carol Bult is a geneticist/bioinformatician whose research program focuses on integrating complex genomic and biological data to facilitate the use of the laboratory mouse as a model system for understanding normal biological and disease processes in humans. Her major projects include 1) the integration of large-scale mouse genome sequence data into the Mouse Genome Informatics database; 2) the creation of a laboratory information management system to support large-scale mutagenesis and phenotyping; 3) the design and implementation of community databases to support basic cancer genetics research using mouse models, and 4) the development of open source software to bridge the "informatics gap" between the activities of computational and wet bench biologists through seamless access to diverse data sources, data analysis tools, and data visualization utilities.
Recent Publications:
Bult CJ, Kibbe WA, Snoddy J, Vitaterna M, Seanson D, Pretel S, Li Y, Hohman MM, Rinchik E, Takahashi JS, Frankel WN, Goldowitz D. 2004. A genome end-game: understanding gene function in the nervous system. Nat Neurosci 7:484-5.
Bult CJ, JA Blake, JE Richardson, JA Kadin, JT Eppig, and the members of the Mouse Genome Database Group. 2004. The Mouse Genome Database (MGD): Integrating biology with the genome. Nucleic Acids Res Jan1:32.
Evsikov A, de Vries WN, Peaston AE, Radford EE, Fancher KS, Chen FH, Blake JA, Bult CJ, Latham KE, Solter D, Knowles BB. 2004. Systems biology of the 2-cell mouse embryo. Cytogenet Genome Res 105:240-250.
Gene Ontology Consortium. 2004. The Gene Ontology(GO) database and informatics resource. Nucleic Acids Res Jan 1:32.
Goldowitz D, Frankel WN, Takahashi JS, Holtz-Vitaterna M, Bult C, Kibbe WA, Snoddy J, Li Y, Pretel S, Yates J, Swanson DJ. 2004. Large –scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function. Molec Brain Res 132:105-115.
Mikaelian I, Nanney LB, Parman KS, Kusewitt DF, Ward JM, Naf D, Krupke DM, Eppig JT, Bult CJ, Seymour R, Ickiki T, Sundberg JP. 2004. Antibodies that label paraffin-embedded mouse tissues: a collaborative endeavor. Toxicol Pathol 32:181-91.
Richardson JE, Kadin JA, Blake JA, Bult CJ, Eppig JT, Ringwald M and the Mouse Genome Informatics Group. 2004. From sipping on a straw to drinking from a fire hose; data integration in a public genome database. Proceedings of the 20th IEEE International Conference on Data Engineering. March 04:795-798.
Eppig JT, Bult CJ, Kadin, JA, Richardson JE, Blake JA and the Mouse Genome Database Group. 2005. The Mouse Genome Database (MGD): From Genes to Mice, A Comprehensive Resource for Mouse Biology. Nucleic Acids Res 33:D471-5
Krupke, DM, Naf D, Vincent MJ, Allio T, Mikaelian I, Sundberg JP, Bult CJ, Eppig JT. 2005. The Mouse Tumor Biology Database: integrated access to mouse cancer biology data. Exp Lung Res 31:259-270.
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